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Antimicrobial Agents and Chemotherapy, May 2005, p. 2112-2115, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2112-2115.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Identification of a Progenitor of the CTX-M-9 Group of Extended-Spectrum ß-Lactamases from Kluyvera georgiana Isolated in Guyana

Adam B. Olson,1 M. Silverman,3 David A. Boyd,2 Allison McGeer,3 Barbara M. Willey,3 V. Pong-Porter,3 N. Daneman,3 and Michael R. Mulvey2*

University of Manitoba, Winnipeg, Manitoba, Canada,1 National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, Canada,2 Mount Sinai Hospital, Toronto, Ontario, Canada3

Received 13 July 2004/ Returned for modification 26 September 2004/ Accepted 17 January 2005

Chromosomal ß-lactamase genes (blaKLUY) from six Kluyvera georgiana strains isolated in Guyana were cloned and expressed in Escherichia coli. KLUY-1 exhibited 100% amino acid identity with the extended-spectrum ß-lactamase CTX-M-14. We also show that a 2.7-kb Kluyvera chromosomal region exhibits 99% nucleotide identity to a portion of In60 that includes blaCTX-M-9.

* Corresponding author. Mailing address: Nosocomial Infections, National Microbiology Laboratory, 1015 Arlington St., Winnipeg, Manitoba, Canada R3E 3R2. Phone: (204) 789-2133. Fax: (204) 789-5020. E-mail: Michael_mulvey{at}hc-sc.gc.ca.

Antimicrobial Agents and Chemotherapy, May 2005, p. 2112-2115, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2112-2115.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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