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Antimicrobial Agents and Chemotherapy, May 2005, p. 2119-2121, Vol. 49, No. 5
0066-4804/05/$08.00+0 doi:10.1128/AAC.49.5.2119-2121.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Sterol Demethylase Gene (cyp51A) of Aspergillus fumigatus
Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
Received 3 December 2004/ Returned for modification 5 January 2005/ Accepted 20 January 2005
The combined activity of different azole drugs was investigated. Thirty-one Aspergillus fumigatus strains were tested, including two cyp51A and one cyp51B gene-knockout strain and azole-susceptible and -resistant strains with different resistance mechanisms. The combination of itraconazole and voriconazole was synergistic for all strains except for those with gene knockouts.
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