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Antimicrobial Agents and Chemotherapy, May 2005, p. 2119-2121, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2119-2121.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Differences in Interactions between Azole Drugs Related to Modifications in the 14-{alpha} Sterol Demethylase Gene (cyp51A) of Aspergillus fumigatus

G. Garcia-Effron, E. Mellado, A. Gomez-Lopez, L. Alcazar-Fuoli, M. Cuenca-Estrella, and Juan L. Rodriguez-Tudela*

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain

Received 3 December 2004/ Returned for modification 5 January 2005/ Accepted 20 January 2005

The combined activity of different azole drugs was investigated. Thirty-one Aspergillus fumigatus strains were tested, including two cyp51A– and one cyp51B– gene-knockout strain and azole-susceptible and -resistant strains with different resistance mechanisms. The combination of itraconazole and voriconazole was synergistic for all strains except for those with gene knockouts.

* Corresponding author. Mailing address: Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo Km 2, 28220 Madrid, Spain. Phone: 34-91-8223919. Fax: 34-91-5097966. E-mail: juanl.rodriguez-tudela{at}isciii.es.

Antimicrobial Agents and Chemotherapy, May 2005, p. 2119-2121, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2119-2121.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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  • Cowen, L. E., Steinbach, W. J. (2008). Stress, Drugs, and Evolution: the Role of Cellular Signaling in Fungal Drug Resistance. Eukaryot Cell 7: 747-764 [Full Text]  


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