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Antimicrobial Agents and Chemotherapy, May 2005, p. 2130-2132, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2130-2132.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Prevalence and Characterization of Invasive Isolates of Streptococcus pyogenes with Reduced Susceptibility to Fluoroquinolones

Jeff Powis,1,2 Allison McGeer,1,2 Carla Duncan,1 Ryan Goren,1 Joyce C. S. de Azavedo,1,2 Darrin J. Bast,1,2 Sylvia Pong-Porter,1 Tony Mazzulli,1,2 Karen Green,1 Barbara Willey,1 and Donald E. Low1,2*

Department of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital,1 University of Toronto, Toronto, Ontario, Canada2

Received 27 September 2004/ Returned for modification 28 December 2004/ Accepted 27 January 2005

Fluoroquinolone susceptibility testing was performed on invasive group A streptococcus isolates from 1992-1993 and 2003 from Ontario, Canada. None were nonsusceptible to levofloxacin. Two of 153 (1.3%) from 1992-1993 and 7 of 160 (4.4%) from 2003 had a levofloxacin MIC of 2 µg/ml; all nine had parC mutations, and eight were serotype M6.

* Corresponding author. Mailing address: Department of Microbiology, Rm. 1487, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario, Canada M5G 1X5. Phone: (416) 586-4435. Fax: (416) 586-8746. E-mail: dlow{at}mtsinai.on.ca.

Antimicrobial Agents and Chemotherapy, May 2005, p. 2130-2132, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2130-2132.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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