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Antimicrobial Agents and Chemotherapy, May 2005, p. 2133-2136, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2133-2136.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Substrate-Dependent Utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK Efflux Pump

Rungtip Chuanchuen,2 Takeshi Murata,3 Naomasa Gotoh,3 and Herbert P. Schweizer1*

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523,1 Department of Veterinary Public Health, Faculty of Veterinary Science, Chulalongkorn University, Patumwan, Bangkok, 10330, Thailand,2 Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto, 6078414, Japan3

Received 13 October 2004/ Returned for modification 4 January 2005/ Accepted 27 January 2005

MexJK requires OprM for erythromycin efflux but not for triclosan efflux. Deletion of 15 OprM family outer membrane proteins (OMPs) revealed that only the TolC homolog OpmH functions with MexJK for triclosan efflux. This is the first report of natural utilization of multiple OMPs by a given resistance nodulation cell division transporter/membrane fusion protein pair.

* Corresponding author. Mailing address: Department of Microbiology, Immunology and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523. Phone: (970) 491-3536. Fax: (970) 491-1815. E-mail: Herbert.Schweizer{at}colostate.edu.

Antimicrobial Agents and Chemotherapy, May 2005, p. 2133-2136, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2133-2136.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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