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Antimicrobial Agents and Chemotherapy, May 2005, p. 2137-2139, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2137-2139.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

High Levels of Antimicrobial Coresistance among Extended-Spectrum-ß-Lactamase-Producing Enterobacteriaceae

Mitchell J. Schwaber,1* Shiri Navon-Venezia,1 David Schwartz,2 and Yehuda Carmeli1

Division of Epidemiology,1 Laboratory of Clinical Microbiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., Tel Aviv 64239, Israel2

Received 22 November 2004/ Returned for modification 13 December 2004/ Accepted 3 January 2005

We compared the susceptibility of 312 extended-spectrum ß-lactamase (ESBL)-producing Enterobacteriaceae isolates with that of 1,216 ESBL nonproducers. Of ESBL producers, 25% were susceptible to gentamicin, 30% to trimethoprim-sulfamethoxazole, 41% to ciprofloxacin, and 60% to piperacillin-tazobactam. ESBL nonproducers were more often susceptible to these agents. ESBL-producing Enterobacteriaceae represent a major source of resistance to various antibiotics.

* Corresponding author. Mailing address: Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., Tel Aviv 64239, Israel. Phone: 972-52-426-6800. Fax: 972-3-697-3256. E-mail: schwm{at}massmed.org.

Antimicrobial Agents and Chemotherapy, May 2005, p. 2137-2139, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2137-2139.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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