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High Levels of Antimicrobial Coresistance among Extended-Spectrum-ß-Lactamase-Producing Enterobacteriaceae

Division of Epidemiology,¹ Laboratory of Clinical Microbiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., Tel Aviv 64239, Israel²

Received 22 November 2004/ Returned for modification 13 December 2004/ Accepted 3 January 2005

We compared the susceptibility of 312 extended-spectrum ß-lactamase (ESBL)-producing Enterobacteriaceae isolates with that of 1,216 ESBL nonproducers. Of ESBL producers, 25% were susceptible to gentamicin, 30% to trimethoprim-sulfamethoxazole, 41% to ciprofloxacin, and 60% to piperacillin-tazobactam. ESBL nonproducers were more often susceptible to these agents. ESBL-producing Enterobacteriaceae represent a major source of resistance to various antibiotics.

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