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Antimicrobial Agents and Chemotherapy, June 2005, p. 2454-2459, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2454-2459.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Mosaic Structure of a Multiple-Drug-Resistant, Conjugative Plasmid from Campylobacter jejuni

Warawadee Nirdnoy,1,2 Carl J. Mason,1 and Patricia Guerry3*

Department of Enteric Diseases, AFRIMS,1 Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand,2 Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland3

Received 15 November 2004/ Returned for modification 6 December 2004/ Accepted 30 January 2005

Partial sequence analysis of a tet(O) plasmid from a multiple-drug-resistant clinical isolate of Campylobacter jejuni revealed 10 genes or pseudogenes encoding different aminoglycoside inactivating enzymes, transposase-like genes, and multiple unknown genes from a variety of pathogenic and commensal bacteria. The plasmid could be mobilized by a P incompatibility group plasmid into Escherichia coli, where it apparently integrated into the chromosome and expressed high-level resistance to multiple aminoglycoside antibiotics. This work provides new information about both the nature of drug resistance in C. jejuni and the ability of C. jejuni to exchange genes with other bacterial species.

* Corresponding author. Mailing address: Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Ave., Silver Spring, MD 20910. Phone: (301) 319-7662. Fax: (301) 319-7679. E-mail: guerryp{at}nmrc.navy.mil.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2454-2459, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2454-2459.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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