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Antimicrobial Agents and Chemotherapy, June 2005, p. 2487-2489, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2487-2489.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Telithromycin against Macrolide-Susceptible and Macrolide-Resistant Pharyngeal Isolates of Group A Streptococci in the United States

Michael Green,1* Coburn Allen,2 John Bradley,3 Barry Dashefsky,4 Janet R. Gilsdorf,5 Mario J. Marcon,6 Gordon E. Schutze,7 Clay Smith,8 Emmanuel Walter,9 Judith M. Martin,1 Kathryn A. Edwards,8 Karen A. Barbadora,1 Renee M. Rumbaugh,1 and Ellen R. Wald1

Department of Pediatrics, Division of Allergy, Immunology and Infectious Diseases, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania,1 Texas Children's Hospital, Houston, Texas,2 Children's Hospital of San Diego, San Diego, California,3 New Jersey Medical School-UMDNJ, Newark, New Jersey,4 Mott's Children's Hospital, Ann Arbor, Michigan,5 Children's Hospital of Columbus, Columbus, Ohio,6 Arkansas Children's Hospital, Little Rock, Arkansas,7 Vanderbilt University Medical Center, Nashville, Tennessee,8 Duke University Medical Center; Durham, North Carolina9

Received 5 October 2004/ Returned for modification 28 December 2004/ Accepted 3 February 2005

In vitro susceptibility testing of 2,797 group A streptococcus (GAS) isolates demonstrated that telithromycin was fully active against all macrolide-susceptible strains and among 80 of 115 macrolide-resistant GAS expressing the M phenotype. Telithromycin resistance was identified in 2 of 45 strains expressing the inducible macrolide-lincosamide-streptogramin B phenotype and four of nine isolates expressing the constitutive macrolide-lincosamide-streptogramin B resistance phenotype.

* Corresponding author. Mailing address: MPH Division of Allergy, Immunology and Infectious Diseases, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213. Phone: (412) 692-7438. Fax: (412) 692-8499. E-mail: michael.green{at}chp.edu.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2487-2489, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2487-2489.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Green, M. D., Beall, B., Marcon, M. J., Allen, C. H., Bradley, J. S., Dashefsky, B., Gilsdorf, J. R., Schutze, G. E., Smith, C., Walter, E. B., Martin, J. M., Edwards, K. M., Barbadora, K. A., Wald, E. R. (2006). Multicentre surveillance of the prevalence and molecular epidemiology of macrolide resistance among pharyngeal isolates of group A streptococci in the USA. J Antimicrob Chemother 57: 1240-1243 [Abstract] [Full Text]  
  • Farrell, D. J., Shackcloth, J., Barbadora, K. A., Green, M. D. (2006). Streptococcus pyogenes Isolates with High-Level Macrolide Resistance and Reduced Susceptibility to Telithromycin Associated with 23S rRNA Mutations. Antimicrob. Agents Chemother. 50: 817-818 [Abstract] [Full Text]  


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