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Antimicrobial Agents and Chemotherapy, June 2005, p. 2495-2497, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2495-2497.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Fluoroquinolone-Resistant Streptococcus agalactiae: Epidemiology and Mechanism of Resistance

Wehbeh Wehbeh,1,2* Roberto Rojas-Diaz,1 Xinying Li,3 Noriel Mariano,1 Louise Grenner,1 Sorana Segal-Maurer,1,2 Barbara Tommasulo,1,2 Karl Drlica,3 Carl Urban,1,2* and James J. Rahal1,2

Infectious Disease Section, Department of Medicine and Lang Research Center, New York Hospital Queens, Flushing, New York,1 Weill Medical College, Cornell University, New York, New York,2 Public Health Research Institute, Newark, New Jersey3

Received 27 October 2004/ Returned for modification 18 January 2005/ Accepted 11 February 2005

Quinolone-resistant Streptococcus agalactiae bacteria were recovered from single-patient isolates and found to contain mutations in the gyrase and topoisomerase IV genes. Pulsed-field gel electrophoresis demonstrated that four isolates from the same long-term care facility were closely related; in seven cases, quinolone-resistant Haemophilus influenzae and S. agalactiae bacteria were isolated from the same patient.

* Corresponding author. Mailing address: New York Hospital Queens, 56-45 Main Street, Flushing, NY 11355. Phone: (718) 670-1525. Fax: (718) 661-7899. E-mail for Carl Urban: cmurban{at}nyp.org. E-mail for Wehbeh Wehbeh: WEW9004{at}nyp.org.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2495-2497, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2495-2497.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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