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Antimicrobial Agents and Chemotherapy, June 2005, p. 2498-2500, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2498-2500.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro and In Vivo Activities of DA-7867, a New Oxazolidinone, against Aerobic Gram-Positive Bacteria

Eun Jeong Yoon,1 Yeong Woo Jo,1,2 Sung Hak Choi,2 Tae Ho Lee,2 Jae Keol Rhee,2 Moohi Yoo,2 Mi Ja Shim,3 and Eung Chil Choi1*

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742,1 Dong-A Pharm. Co., Ltd., Research Lab., Yongin 449-905,2 Department of Life Science, The University of Seoul, Seoul 130-743, Korea3

Received 22 September 2004/ Returned for modification 28 November 2004/ Accepted 8 February 2005

In vitro and in vivo activities of DA-7867 were assessed against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and penicillin-resistant Streptococcus pneumoniae. All isolates were inhibited by DA-7867 at ≤0.78 µg/ml, a four-times-lower concentration than that of inhibition by linezolid. For murine infection models, DA-7867 also exhibited greater efficacy than linezolid against all isolates tested.

* Corresponding author. Mailing address: Department of Microbiology, College of Pharmacy, Seoul National University, San 56-1, Shillim-9 dong, Kwanak-gu, Seoul 151-742, Korea. Phone: 82 (2) 880-7874. Fax: 82 (2) 886-5802. E-mail: ecchoi{at}snu.ac.kr.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2498-2500, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2498-2500.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • McKee, E. E., Ferguson, M., Bentley, A. T., Marks, T. A. (2006). Inhibition of Mammalian mitochondrial protein synthesis by oxazolidinones.. Antimicrob. Agents Chemother. 50: 2042-2049 [Abstract] [Full Text]  


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