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Antimicrobial Agents and Chemotherapy, June 2005, p. 2501-2503, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2501-2503.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Biosynthesized Tea Polyphenols Inactivate Chlamydia trachomatis In Vitro

Tsutomu Yamazaki,1,2* Toshio Kishimoto,1 Sadashi Shiga,1 Kozue Sato,1 Toshikatsu Hagiwara,1 Miyuki Inoue,2 Nozomu Sasaki,2 Kazunobu Ouchi,3 and Yukihiko Hara4

Department of Virology 1, National Institute of Infectious Diseases, Tokyo,1 Department of Pediatrics, Saitama Medical School, Saitama,2 Department of Pediatrics 2, Kawasaki Medical School, Kurashiki,3 Food Research Laboratories, Mitsui Norin Co., Shizuoka, Japan4

Received 2 September 2004/ Returned for modification 23 November 2004/ Accepted 4 February 2005

Biosynthesized tea polyphenols showed antichlamydial activity against Chlamydia trachomatis D/UW-3/Cx and L2/434/Bu using cell culture. The most active compounds were (–)-epigallocatechin gallate and (–)-epicatechin gallate, followed by (–)-epicatechin (EC). (+)-Epicatechin and (–)-epigallocatechin were intermediate. EC was the least toxic. These results warrant evaluation of tea polyphenols as topical antichlamydial agents.

* Corresponding author. Mailing address: Department of Virology 1, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku, Tokyo, Japan 162-8640. Phone: 81-3-5285-1111. Fax: 81-3-5285-1208. E-mail: tochaben{at}gray.plala.or.jp.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2501-2503, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2501-2503.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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