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Antimicrobial Agents and Chemotherapy, June 2005, p. 2504-2506, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2504-2506.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Population Pharmacokinetics of Abacavir in Plasma and Cerebrospinal Fluid

Edmund V. Capparelli,1* Scott L. Letendre,2 Ronald J. Ellis,2 Parul Patel,1 Diane Holland,1 and J. Allen McCutchan2

Pediatric Pharmacology Research Unit,1 HIV Neurobehavioral Research Center Group, University of California, San Diego, California2

Received 10 September 2004/ Returned for modification 3 January 2005/ Accepted 15 February 2005

The distribution of abacavir into the cerebrospinal fluid (CSF) was assessed by use of a population pharmacokinetic analysis. Plasma and CSF abacavir concentrations in 54 subjects were determined. The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetrates into the CSF in adequate concentrations to inhibit local human immunodeficiency virus replication.

* Corresponding author. Mailing address: Pediatric Pharmacology Research Unit (PPRU), University of California, San Diego, 200 West Arbor Drive, MC 8214, San Diego, CA 92103-8214. Phone: (619) 497-2105. Fax: (619) 497-2101. E-mail: ecapparelli{at}ucsd.edu.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2504-2506, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2504-2506.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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  • Shaik, N., Giri, N., Pan, G., Elmquist, W. F. (2007). P-glycoprotein-Mediated Active Efflux of the Anti-HIV1 Nucleoside Abacavir Limits Cellular Accumulation and Brain Distribution. Drug Metab. Dispos. 35: 2076-2085 [Abstract] [Full Text]  


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