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Antimicrobial Agents and Chemotherapy, June 2005, p. 2519-2521, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2519-2521.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Inhibitory Effects of Hinokitiol on Proliferation of Chlamydia trachomatis

Hiroaki Yamano,1,2 Tsutomu Yamazaki,1,3* Kozue Sato,1 Sadashi Shiga,1 Toshikatsu Hagiwara,1 Kazunobu Ouchi,4 and Toshio Kishimoto1

National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640,1 Department of Research and Development, Fuji Latex Co., Ltd., Tochigi, Tochigi 328-0006,2 Department of Pediatrics, Saitama Medical School, Iruma, Saitama 350-0495,3 Department of Pediatrics 2, Kawasaki Medical School, Kurashiki, Japan4

Received 4 October 2004/ Returned for modification 14 December 2004/ Accepted 18 February 2005

The inhibitory effects of hinokitiol (ß-thujaplicin) on Chlamydia trachomatis D/UW-3/Cx were shown by MIC, minimum lethal concentration (MLC), and preinoculation minimal microbicidal concentration assays using HeLa 229 cells. The MIC and the MLC were both 32 µg/ml. Further evaluation of hinokitiol as a topical agent against C. trachomatis is warranted.

* Corresponding author. Mailing address: Department of Virology 1, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, Japan 162-8640. Phone: 81-3-5285-1111. Fax: 81-3-5285-1208. E-mail: tochaben{at}gray.plala.or.jp.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2519-2521, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2519-2521.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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