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Antimicrobial Agents and Chemotherapy, June 2005, p. 2528-2532, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2528-2532.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Effect of CYP3A1(23) Induction on Clarithromycin Pharmacokinetics in Rats with Diabetes Mellitus

Yu C. Kim,1 Joo H. Lee,1 So H. Kim,2 and Myung G. Lee1*

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742,1 Department of Pharmacology, College of Dentistry and Research Institute of Oral Science, Kangnung National University, 120, Gangneung Daehangno, Gangneung, Kangwon-Do 210-702, South Korea2

Received 16 July 2004/ Returned for modification 25 January 2005/ Accepted 16 February 2005

After intravenous and oral administration of clarithromycin at a dose of 20 mg/kg of body weight to rats with diabetes mellitus induced by alloxan (DMIA) and diabetes mellitus induced by streptozotocin (DMIS), the area under the curve values were significantly smaller than those of respective control rats. The in vitro intrinsic clearance values for the disappearance of clarithromycin were significantly faster in both rats with DMIA and rats with DMIS than in control rats. The above data suggested that metabolism of clarithromycin increased in both types of diabetic rat due to an increase in the expression and mRNA level of CYP3A1(23) in the rats.

* Corresponding author. Mailing address: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, South Korea. Phone: 822-880-7855. Fax: 822-889-8693. E-mail: leemg{at}snu.ac.kr.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2528-2532, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2528-2532.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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