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Antimicrobial Agents and Chemotherapy, June 2005, p. 2533-2535, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2533-2535.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro and Intracellular Activities of LBM415 (NVP PDF-713) against Legionella pneumophila

Paul H. Edelstein,1,2* Baofeng Hu,1 and Martha A. C. Edelstein1

Departments of Pathology and Laboratory Medicine,1 Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-42832

Received 17 September 2004/ Returned for modification 14 January 2005/ Accepted 4 February 2005

LBM415 activity against extracellular and intracellular Legionella pneumophila was studied. The LBM415 MIC50 for 20 Legionella sp. strains was 4 µg/ml, versus 0.06, 0.25, and ≤ 0.03 µg/ml for azithromycin, erythromycin, and levofloxacin, respectively. LBM415 (0.5 and 16 µg/ml) reversibly prevented intracellular growth of two L. pneumophila strains and was less active than erythromycin.

* Corresponding author. Mailing address: Clinical Microbiology Laboratory, Hospital of the University of Pennsylvania, 4 Gates, 3400 Spruce Street, Philadelphia, PA 19104-4283. Phone: (215) 662-6651. Fax: (215) 662-6655. E-mail: phe{at}mail.med.upenn.edu.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2533-2535, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2533-2535.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Bogdanovich, T., Smith, K. A., Clark, C., Pankuch, G. A., Lin, G., McGhee, P., Dewasse, B., Appelbaum, P. C. (2006). Activity of LBM415 Compared to Those of 11 Other Agents against Haemophilus Species. Antimicrob. Agents Chemother. 50: 2323-2329 [Abstract] [Full Text]  


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