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Antimicrobial Agents and Chemotherapy, June 2005, p. 2541-2542, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2541-2542.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Comparative In Vitro Activities of Investigational Peptide Deformylase Inhibitor NVP LBM-415 and Other Agents against Human Mycoplasmas and Ureaplasmas

Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249

Received 10 December 2004/ Returned for modification 27 January 2005/ Accepted 31 January 2005

Peptide deformylase inhibitor LBM-415 and seven other drugs were tested against Mycoplasma pneumoniae (100 isolates), Mycoplasma hominis (20 isolates), Mycoplasma fermentans (10 isolates), and Ureaplasma species (50 isolates). LBM-415 was active against M. pneumoniae (MICs, 0.008 µg/ml). It showed no activity against M. hominis and M. fermentans and modest activity against Ureaplasma spp.

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