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Antimicrobial Agents and Chemotherapy, June 2005, p. 2543-2545, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2543-2545.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Selection of Cross-Resistance following Exposure of Pseudomonas aeruginosa Clinical Isolates to Ciprofloxacin or Cefepime

Samer A. Alyaseen,1 Kerryl E. Piper,1 Mark S. Rouse,1 James M. Steckelberg,1 and Robin Patel1,2*

Division of Infectious Diseases, Department of Internal Medicine,1 Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota2

Received 29 September 2004/ Returned for modification 22 November 2004/ Accepted 18 February 2005

Exposure of ciprofloxacin- and cefepime-susceptible Pseudomonas aeruginosa isolates to increasing concentrations of ciprofloxacin selected for ciprofloxacin resistance in 26/27 and cefepime nonsusceptibility in 7/27 isolates. Exposure of the isolates to increasing concentrations of cefepime selected for cefepime nonsusceptibility in 20/27 isolates but not for ciprofloxacin resistance.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 First St. SW, Rochester, MN 55905. Phone: (507) 255-6482. Fax: (507) 255-7767. E-mail: patel.robin{at}mayo.edu.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2543-2545, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2543-2545.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pena, C., Guzman, A., Suarez, C., Dominguez, M. A., Tubau, F., Pujol, M., Gudiol, F., Ariza, J. (2007). Effects of Carbapenem Exposure on the Risk for Digestive Tract Carriage of Intensive Care Unit-Endemic Carbapenem-Resistant Pseudomonas aeruginosa Strains in Critically Ill Patients. Antimicrob. Agents Chemother. 51: 1967-1971 [Abstract] [Full Text]  


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