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Antimicrobial Agents and Chemotherapy, June 2005, p. 2550-2553, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2550-2553.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

ErmB Determinants and Tn916-Like Elements in Clinical Isolates of Clostridium difficile

Patrizia Spigaglia, Valentina Carucci, Fabrizio Barbanti, and Paola Mastrantonio*

Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy

Received 11 November 2004/ Returned for modification 19 December 2004/ Accepted 11 February 2005

Erythromycin and tetracycline resistance was analyzed in 37 Clostridium difficile clinical isolates. Strains of different clonal origins showed different erythromycin and tetracycline resistance determinants and different genetic arrangements of the elements. In strains of recent isolation, the presence of Tn916-like elements, never found before in C. difficile clinical isolates, has been demonstrated.

* Corresponding author. Mailing address: Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 39 06 49902335. Fax: 39 06 49387112. E-mail: pmastran{at}iss.it.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2550-2553, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2550-2553.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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