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Antimicrobial Agents and Chemotherapy, June 2005, p. 2554-2557, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2554-2557.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Levofloxacin Disposition over Time in Aqueous Humor of Patients Undergoing Cataract Surgery

Federico Pea,^1* Ettore Ferrari,^2,3 Federica Pavan,¹ Derri Roman-Pognuz,² Francesco Bandello,² and Mario Furlanut¹

Institute of Clinical Pharmacology and Toxicology, Department of Experimental and Clinical Pathology and Medicine, Medical School, University of Udine, Udine, Italy,¹ Department of Ophthalmology, Medical School, University of Udine, Udine, Italy,² Division of Ophthalmology, Palmanova Hospital, Palmanova, Udine, Italy³

Received 22 September 2004/ Returned for modification 3 January 2005/ Accepted 31 January 2005

The ocular disposition of levofloxacin in patients receiving two 500-mg oral doses 10 h apart before cataract surgery was assessed with the intent of defining drug ocular exposure over time. The mean aqueous humor concentrations persisted above 1.5 mg/liter between 1.5 and 6.0 h after the second dose, with average aqueous-to-plasma ratios ranging between 0.33 and 0.57. This favorable ocular disposition provides support for trials of systemic levofloxacin for prophylaxis of postoperative endophthalmitis in selected patients or as adjunctive therapy for the treatment of this potentially devastating infective complication.

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* Corresponding author. Mailing address: Institute of Clinical Pharmacology and Toxicology, DPMSC, University of Udine, P. le S. Maria della Misericordia 3, 33100 Udine, Italy. Phone and fax: 39 0432 559833. E-mail: federico.pea{at}med.uniud.it.

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Antimicrobial Agents and Chemotherapy, June 2005, p. 2554-2557, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2554-2557.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

This article has been cited by other articles:

• Ferrer, C, Rodriguez, A, Abad, J L, Fernandez, J, Alio, J L (2008). Bactericidal effect of intravitreal levofloxacin in an experimental model of endophthalmitis. Br J Ophthalmol 92: 678-682 [Abstract] [Full Text]