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Antimicrobial Agents and Chemotherapy, June 2005, p. 2561-2564, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2561-2564.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Decreasing Prevalence of ß-Lactamase Production among Respiratory Tract Isolates of Haemophilus influenzae in the United States

Kris P. Heilmann, Cassie L. Rice, Ashley L. Miller, Norma J. Miller, Susan E. Beekmann, Michael A. Pfaller, Sandra S. Richter, and Gary V. Doern*

Division of Medical Microbiology, Department of Pathology, Roy J. and Lucille A. Carver University of Iowa College of Medicine, Iowa City, Iowa

Received 27 December 2004/ Returned for modification 20 January 2005/ Accepted 26 February 2005

A total of 986 isolates of Haemophilus influenzae from patients with respiratory tract infections in 45 United States medical centers were characterized during the winter of 2002-2003. ß-Lactamase production was noted with 26.2% of isolates; 14.6% were resistant to trimethoprim-sulfamethoxazole. Resistance to other relevant antimicrobial agents was extremely uncommon. In comparison to the results of four previous national surveys conducted since 1994, the prevalence of ß-lactamase production with this pathogen appears to be decreasing.

* Corresponding author. Mailing address: Medical Microbiology Division Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242. Phone: (319) 356-8616. Fax: (319) 356-4916. E-mail: gary-doern{at}uiowa.edu.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2561-2564, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2561-2564.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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