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Antimicrobial Agents and Chemotherapy, July 2005, p. 2986-2989, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.2986-2989.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Macrolide Roxithromycin Impairs NADPH Oxidase Activation and Alters Translocation of Its Cytosolic Components to the Neutrophil Membrane In Vitro

Houria Abdelghaffar,1 Catherine Babin-Chevaye,2 and Marie-Thérèse Labro2*

Université Hassan II, Faculté des Sciences et Techniques Mohammedia, Département de Biologie, Unité de Biotechnologies de l'Environnement et de la Santé, BP 146 Mohammedia, Morocco,1 INSERM U479, CHU Xavier Bichat, Paris, France2

Received 23 November 2004/ Returned for modification 4 February 2005/ Accepted 3 April 2005

We have studied the interference of roxithromycin with NADPH oxidase, the key enzymatic system for oxidant production by human neutrophils. Roxithromycin alters the reconstitution of an active enzyme and impairs the translocation to the outer membrane of the cytosolic components p47-phox and p67-phox. Interestingly, in resting cells roxithromycin directly triggers the translocation of these factors without stimulating the oxidative burst.

* Corresponding author. Mailing address: INSERM U 479, CHU Xavier Bichat, 16 rue Henri Huchard, 75018 Paris, France. Phone: 33 1 44 85 62 06. Fax: 33 1 44 85 62 07. E-mail: labro{at}bichat.inserm.fr.

Antimicrobial Agents and Chemotherapy, July 2005, p. 2986-2989, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.2986-2989.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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