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Antimicrobial Agents and Chemotherapy, July 2005, p. 2990-2993, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.2990-2993.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Association between Resistance to Erythromycin and the Presence of the Fibronectin Binding Protein F1 Gene, prtF1, in Streptococcus pyogenes Isolates from German Pediatric Patients

Maria Haller, Kirsten Fluegge, Sandra Jasminder Arri, Brit Adams, and Reinhard Berner*

Department of Pediatrics and Adolescent Medicine, University Hospital of Freiburg, Freiburg, Germany

Received 27 October 2004/ Returned for modification 12 December 2004/ Accepted 15 March 2005

A total of 301 German pediatric group A streptococcus isolates were screened for the presence of macrolide resistance and the fibronectin binding protein F1 gene (prtF1) encoding an adhesin and cell invasiveness protein. The prtF1 gene was present significantly more often among macrolide-resistant isolates. The majority of these were not clonally related.

* Corresponding author. Mailing address: Department of Pediatrics and Adolescent Medicine, University Hospital of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany. Phone: 49-761-270-4519. Fax: 49-761-270-4598. E-mail: berner{at}kikli.ukl.uni-freiburg.de.

Antimicrobial Agents and Chemotherapy, July 2005, p. 2990-2993, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.2990-2993.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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