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Antimicrobial Agents and Chemotherapy, July 2005, p. 3018-3020, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3018-3020.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Emergence of KPC-Possessing Klebsiella pneumoniae in Brooklyn, New York: Epidemiology and Recommendations for Detection

Department of Medicine, SUNY-Downstate Medical Center,¹ Department of Microbiology, Kings County Hospital,² Department of Pathology Services, Coney Island Hospital, Brooklyn, New York³

Received 14 February 2005/ Returned for modification 24 March 2005/ Accepted 3 April 2005

Among 257 isolates of Klebsiella pneumoniae collected in Brooklyn, NY, 24% were found to possess bla_KPC. Clinical microbiology laboratories that used automated broth microdilution systems reported 15% of the KPC-possessing isolates as susceptible to imipenem. The imipenem MIC was found to be markedly affected by the inoculum. For accurate detection of KPC-possessing K. pneumoniae, particular attention should be paid to proper inoculum preparation for broth-based susceptibility methods. In addition, using ertapenem or meropenem for class reporting of carbapenem susceptibility will improve detection.

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