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Antimicrobial Agents and Chemotherapy, July 2005, p. 3031-3033, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3031-3033.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Predominance of 23S rRNA Mutants among Non-Erm, Non-Mef Macrolide-Resistant Clinical Isolates of Streptococcus pneumoniae Collected in the United States in 1999-2000

Todd A. Davies,1* Karen Bush,1 Daniel Sahm,3 and Alan Evangelista2

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.,1 Ortho-McNeil Pharmaceutical, Inc., Raritan, New Jersey,2 Focus Bio-Inova, Herndon, Virginia3

Received 12 January 2005/ Returned for modification 31 January 2005/ Accepted 6 March 2005

A total of 322 erythromycin-resistant pneumococci from TRUST 3 and TRUST 4 United States surveillance studies (1999-2000) were screened for 23S rRNA, L4, and L22 gene mutations. Nineteen isolates, two with mefA, had mutations at position 2058 or 2059 in 23S rRNA. Two had a 69GTG71-to-TPS substitution in L4; one of these also contained ermA.

* Corresponding author. Mailing address: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Room B225, 1000 Route 202, Raritan, NJ 08869. Phone: (908) 707-3465. Fax: (908) 707-3501. E-mail: tdavies{at}prdus.jnj.com.

Antimicrobial Agents and Chemotherapy, July 2005, p. 3031-3033, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3031-3033.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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  • Camilli, R., Del Grosso, M., Iannelli, F., Pantosti, A. (2008). New Genetic Element Carrying the Erythromycin Resistance Determinant erm(TR) in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 52: 619-625 [Abstract] [Full Text]  
  • Wierzbowski, A. K., Nichol, K., Laing, N., Hisanaga, T., Nikulin, A., Karlowsky, J. A., Hoban, D. J., Zhanel, G. G. (2007). Macrolide resistance mechanisms among Streptococcus pneumoniae isolated over 6 years of Canadian Respiratory Organism Susceptibility Study (CROSS) (1998 2004). J Antimicrob Chemother 60: 733-740 [Abstract] [Full Text]  


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