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Antimicrobial Agents and Chemotherapy, July 2005, p. 3031-3033, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3031-3033.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Predominance of 23S rRNA Mutants among Non-Erm, Non-Mef Macrolide-Resistant Clinical Isolates of Streptococcus pneumoniae Collected in the United States in 1999-2000

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.,¹ Ortho-McNeil Pharmaceutical, Inc., Raritan, New Jersey,² Focus Bio-Inova, Herndon, Virginia³

Received 12 January 2005/ Returned for modification 31 January 2005/ Accepted 6 March 2005

A total of 322 erythromycin-resistant pneumococci from TRUST 3 and TRUST 4 United States surveillance studies (1999-2000) were screened for 23S rRNA, L4, and L22 gene mutations. Nineteen isolates, two with mefA, had mutations at position 2058 or 2059 in 23S rRNA. Two had a ₆₉GTG₇₁-to-TPS substitution in L4; one of these also contained ermA.

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