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Antimicrobial Agents and Chemotherapy, July 2005, p. 3040-3045, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3040-3045.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Antibacterial Activity of DX-619, a Novel Des-Fluoro(6) Quinolone

Katsuko Fujikawa,* Megumi Chiba, Mayumi Tanaka, and Kenichi Sato

New Product Research Laboratories I, Daiichi Pharmaceutical Co. Ltd., Tokyo, Japan

Received 13 September 2004/ Returned for modification 12 December 2004/ Accepted 28 March 2005

The in vitro activities of DX-619, des-fluoro(6) quinolone, against 1,208 clinical isolates were examined. DX-619 was particularly potent against staphylococci, including ciprofloxacin- and methicillin-resistant strains; the MIC at which 90% of the strains tested were inhibited was 0.5 µg/ml. In addition, DX-619 was also active against gram-negative bacteria.

* Corresponding author. Mailing address: New Product Research Laboratories I, Daiichi Pharmaceutical Co. Ltd., 16-13 Kitakasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan. Phone: 81-3-5696-8236. Fax: 81-3-5696-4264. E-mail: fujikzsl{at}daiichipharm.co.jp.

Antimicrobial Agents and Chemotherapy, July 2005, p. 3040-3045, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3040-3045.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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