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Antimicrobial Agents and Chemotherapy, July 2005, p. 3046-3049, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3046-3049.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Novel Spectinomycin/Streptomycin Resistance Gene, aadA14, from Pasteurella multocida

Corinna Kehrenberg,1 Boudewijn Catry,2 Freddy Haesebrouck,3 Aart de Kruif,2 and Stefan Schwarz1*

Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), Höltystr. 10, 31535 Neustadt-Mariensee, Germany,1 Department of Obstetrics, Reproduction and Herd Health,2 Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, B-9820 Merelbeke, Belgium3

Received 28 February 2005/ Returned for modification 3 April 2005/ Accepted 21 April 2005

A novel spectinomycin/streptomycin resistance gene, designated aadA14, was detected on the mobilizable 5,198-bp plasmid pCCK647 from Pasteurella multocida. The aadA14 gene encodes an aminoglycoside adenylyltransferase of 261 amino acids. Sequence comparisons revealed that the AadA14 protein showed less than 60% identity to the AadA proteins known so far.

* Corresponding author. Mailing address: Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), Höltystr. 10, 31535 Neustadt-Mariensee, Germany. Phone: 49-5034-871-241. Fax: 49-5034-871-246. E-mail: stefan.schwarz{at}fal.de.

Antimicrobial Agents and Chemotherapy, July 2005, p. 3046-3049, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3046-3049.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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