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Antimicrobial Agents and Chemotherapy, July 2005, p. 3059-3061, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3059-3061.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Induction of Telithromycin Resistance by Erythromycin in Isolates of Macrolide-Resistant Staphylococcus spp.

Kepler A. Davis,1* Sharon A. Crawford,2 Kristin R. Fiebelkorn,2 and James H. Jorgensen2

Infectious Diseases Service, Department of Medicine, Brooke Army Medical Center, Ft. Sam Houston, Texas 78234,1 Department of Pathology, The University of Texas Health Science Center, San Antonio, Texas 782292

Received 24 November 2004/ Returned for modification 19 January 2005/ Accepted 3 March 2005

Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not discriminate between resistance due to an efflux mechanism (msrA) or a ribosomal target modification (ermA or ermC). Inducible telithromycin resistance in staphylococci does not appear to be analogous to inducible clindamycin resistance.

* Corresponding author. Mailing address: Infectious Disease Service, Department of Medicine, Brooke Army Medical Center, Ft. Sam Houston, TX 78234. Phone: (210) 916-5554. Fax: (210) 916-0388. E-mail: kepler.davis{at}amedd.army.mil.

Antimicrobial Agents and Chemotherapy, July 2005, p. 3059-3061, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3059-3061.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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  • Depardieu, F., Podglajen, I., Leclercq, R., Collatz, E., Courvalin, P. (2007). Modes and Modulations of Antibiotic Resistance Gene Expression. Clin. Microbiol. Rev. 20: 79-114 [Abstract] [Full Text]  


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