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Antimicrobial Agents and Chemotherapy, July 2005, p. 3070-3072, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3070-3072.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Differences in the DNA Sequences in the Upstream Attenuator Region of erm(A) in Clinical Isolates of Streptococcus pyogenes and Their Correlation with Macrolide/Lincosamide Resistance

Stella Z. Doktor* and Virginia Shortridge{dagger}

Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois

Received 20 January 2005/ Returned for modification 27 March 2005/ Accepted 17 April 2005

The regulatory regions of 52 erm(A) [formerly erm(TR)] clinical Streptococcus pyogenes isolates were studied. Differences in the upstream regulatory region of erm(A) correlated with macrolide/lincosamide resistance patterns. Nine macrolide/lincosamide/streptogramin B-resistant isolates had changes in the leader sequence of erm(A) including base changes, insertions, or deletions. Isolates were also emm typed.

* Corresponding author. Mailing address: AP10-103, Dept. R4MJ, 100 Abbott Park Rd., Abbott Park, IL 60064. Phone: (847) 935-8044. Fax: (847) 938-1674. E-mail: stella.z.doktor{at}abbott.com.

{dagger} Present address: bioMerieux Inc., 595 Anglum Road, Hazelwood, MO 63042.

Antimicrobial Agents and Chemotherapy, July 2005, p. 3070-3072, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3070-3072.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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