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Antimicrobial Agents and Chemotherapy, July 2005, p. 3083-3086, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3083-3086.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Cooperative Uptake of Microcin E492 by Receptors FepA, Fiu, and Cir and Inhibition by the Siderophore Enterochelin and Its Dimeric and Trimeric Hydrolysis Products

Erwin Strahsburger, Marcelo Baeza, Octavio Monasterio, and Rosalba Lagos*

Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile

Received 8 February 2005/ Returned for modification 11 March 2005/ Accepted 18 March 2005

Microcin E492 uptake by FepA, Fiu, and Cir is cooperative, with FepA being the main receptor. No TonB-mediated interaction with the ferric catecholate receptors is needed for microcin to exert action at the cytoplasmic membrane. Microcin E492 uptake by the receptors is inhibited by the dimer and trimer of dihydroxybenzoylserine.

* Corresponding author. Mailing address: Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile. Phone: 56-2-678-7338. Fax: 56-2-276-3870. E-mail: rolagos{at}uchile.cl.

Antimicrobial Agents and Chemotherapy, July 2005, p. 3083-3086, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3083-3086.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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