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Antimicrobial Agents and Chemotherapy, July 2005, p. 3091-3094, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3091-3094.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Association of Plasmid-Mediated Quinolone Resistance with Extended-Spectrum ß-Lactamase VEB-1

Laurent Poirel, Marc Van De Loo, Hedi Mammeri, and Patrice Nordmann*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 Le Kremlin-Bicêtre, France

Received 10 December 2004/ Returned for modification 5 February 2005/ Accepted 12 March 2005

Association of the plasmid-mediated quinolone resistance determinant QnrA and the blaVEB-1 gene was identified in a single Enterobacter cloacae isolate from K.-Bicêtre, France, and in 11 out of 23 blaVEB-1-positive enterobacterial isolates from Bangkok, Thailand. This result may explain in part the association between quinolone and extended-spectrum ß-lactam resistance.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, July 2005, p. 3091-3094, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3091-3094.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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