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Antimicrobial Agents and Chemotherapy, August 2005, p. 3489-3491, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3489-3491.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Efficacy of the Combination of Ciprofloxacin and Cefotaxime against Vibrio vulnificus

Dong-Min Kim,1 Yong Lym,2 Sook Jin Jang,3* Hulin Han,3 Young Gi Kim,4 Choon-Hae Chung,1 and Soon Pyo Hong1

Division of Infectious Disease, Department of Internal Medicine,1 Department of Microbiology,2 Department of Laboratory Medicine, Chosun University College of Medicine, Clinical Research Institute, Gwang-Ju,3 R & D Center of Pharmaceuticals, CJ Corp., Kyonggi-Do, South Korea4

Received 1 February 2005/ Returned for modification 15 February 2005/ Accepted 25 April 2005

We performed time-kill studies of antimicrobial combinations that included minocycline, cefotaxime, and ciprofloxacin with Vibrio vulnificus ATCC 27562. Cefotaxime-plus-ciprofloxacin combinations acted synergistically against V. vulnificus in vitro, and this combination regimen can be a good choice as the empirical treatment for suspected necrotizing fasciitis due to V. vulnificus.

* Corresponding author. Mailing address: Department of Laboratory Medicine, Chosun University Medical School, 588 Seoseok-dong, Dong-gu, Gwang-Ju 501-717, South Korea. Phone: 82-62-220-3259. Fax: 82-62-232-2063. E-mail: sjbjang{at}chosun.ac.kr.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3489-3491, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3489-3491.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Roig, F. J., Llorens, A., Fouz, B., Amaro, C. (2009). Spontaneous Quinolone Resistance in the Zoonotic Serovar of Vibrio vulnificus. Appl. Environ. Microbiol. 75: 2577-2580 [Abstract] [Full Text]  
  • Liu, J.-W., Lee, I.-K., Tang, H.-J., Ko, W.-C., Lee, H.-C., Liu, Y.-C., Hsueh, P.-R., Chuang, Y.-C. (2006). Prognostic Factors and Antibiotics in Vibrio vulnificus Septicemia.. Arch Intern Med 166: 2117-2123 [Abstract] [Full Text]  


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