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Antimicrobial Agents and Chemotherapy, August 2005, p. 3492-3494, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3492-3494.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

First Detection of a Carbapenem-Hydrolyzing Metalloenzyme in Two Enterobacteriaceae Isolates in Spain

M. Teresa Tórtola,1 Susana Lavilla,1 Elisenda Miró,2 Juan José González,1 Nieves Larrosa,1 Montserrat Sabaté,1 Ferran Navarro,2 and Guillermo Prats1*

Department of Microbiology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain,1 Department of Microbiology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain2

Received 31 March 2005/ Returned for modification 15 April 2005/ Accepted 25 April 2005

Two strains of Enterobacteriaceae, Escherichia coli and Klebsiella pneumoniae, producing VIM-1 were isolated for the first time in Spain. In both strains, blaVIM-1 was found to be carried on a gene cassette inserted into a class 1 integron. The blaVIM-1-containing integron was located on a transferable plasmid.

* Corresponding author. Mailing address: Servicio de Microbiología, Hospital Vall d'Hebron, Pg. Vall d'Hebron 119-129, 08035 Barcelona, Spain. Phone: 34-93-2746817. Fax: 34-93-2746801. E-mail: gprats{at}vhebron.net.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3492-3494, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3492-3494.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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