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Antimicrobial Agents and Chemotherapy, August 2005, p. 3498-3500, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3498-3500.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Synergistic Interaction between Amphotericin B and Micafungin against Scedosporium spp.

Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain

Received 15 February 2005/ Returned for modification 23 March 2005/ Accepted 2 May 2005

The in vitro interaction between amphotericin B and micafungin against 36 isolates of Scedosporium spp. has been evaluated using checkerboard assays and the minimal effective concentration endpoint. Synergy was found for 82.4% of Scedosporium prolificans isolates and for 31.6% of Scedosporium apiospermum isolates. Antagonism was not observed.

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