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Antimicrobial Agents and Chemotherapy, August 2005, p. 3520-3522, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3520-3522.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of the First Telithromycin-Resistant Streptococcus pneumoniae Isolate in Germany

Ralf René Reinert,* Mark van der Linden, and Adnan Al-Lahham

Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, D-52057 Aachen, Germany

Received 11 April 2005/ Returned for modification 27 April 2005/ Accepted 14 May 2005

A total of 486 Streptococcus pneumoniae isolates were collected in 2003 and 2004 in Germany and revealed the following resistance rates: penicillin G (7.2%) and erythromycin A (18.9%). Telithromycin exhibited good in vitro activity (MIC at which 90% of the isolates tested were inhibited, 0.125 µg/ml). However, one erm(B)-positive isolate was found to be telithromycin resistant (MIC, 8 µg/ml).

* Corresponding author. Mailing address: Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, Pauwelsstrasse 30, D-52057 Aachen, Germany. Phone: 49 241 8089787. Fax: 49 241 8082483. E-mail: Reinert{at}rwth-aachen.de.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3520-3522, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3520-3522.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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