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Antimicrobial Agents and Chemotherapy, August 2005, p. 3523-3525, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3523-3525.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Origin of Plasmid-Mediated Quinolone Resistance Determinant QnrA

Laurent Poirel,1 Jose-Manuel Rodriguez-Martinez,1,2 Hedi Mammeri,1 Alain Liard,1 and Patrice Nordmann1*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 K.-Bicêtre, France,1 University Hospital Virgen Macarena, University of Sevilla, Sevilla, Spain2

Received 15 March 2005/ Returned for modification 19 April 2005/ Accepted 21 May 2005

Plasmid-mediated resistance to quinolones is increasingly reported in studies of Enterobacteriaceae. Using a PCR-based strategy, a series of gram-negative species were screened for qnrA-like genes. Shewanella algae, an environmental species from marine and fresh water, was identified as its reservoir. This is a one of the very few examples of progenitor identification of an acquired antibiotic resistance gene.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78, rue du General Leclerc, 94275 Le Kremlin-Bicêtre, France. Phone: 33 1 45 21 36 32. Fax: 33 1 45 21 63 40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3523-3525, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3523-3525.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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