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Antimicrobial Agents and Chemotherapy, August 2005, p. 3526-3528, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3526-3528.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Therapeutic Effect of ME1036 on Endocarditis Experimentally Induced by Methicillin-Resistant Staphylococcus aureus

Jun Nagura,* Koji Kijima, Mizuyo Kurazono, Sho Takahata, Toshie Sugano, Yukari Tanaka, Yoko Hirai, Keiko Yamada, Yoshihiro Takayama, Eiki Shitara, and Minoru Yonezawa

Pharmaceutical Research Department, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan

Received 23 August 2004/ Returned for modification 30 November 2004/ Accepted 20 April 2005

The efficacy of ME1036, a novel parenteral carbapenem, was compared with that of vancomycin by using a rabbit model of methicillin-resistant Staphylococcus aureus (MRSA) endocarditis. Compared with vancomycin, ME1036 reduced the bacterial counts in the vegetations at a lower dosage or over a shorter period of administration when it was used for the treatment of MRSA endocarditis.

* Corresponding author. Mailing address: Pharmaceutical Research Department, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan. Phone: 81-45-545-3178. Fax: 81-45-541-2359. E-mail: jun_nagura{at}meiji.co.jp.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3526-3528, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3526-3528.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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