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Antimicrobial Agents and Chemotherapy, August 2005, p. 3538-3540, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3538-3540.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

First Nosocomial Outbreak of Pseudomonas aeruginosa Producing an Integron-Borne Metallo-ß-Lactamase (VIM-2) in the United States

K. Lolans,1 A. M. Queenan,2 K. Bush,2 A. Sahud,1 and J. P. Quinn1*

John H. Stroger, Jr. Hospital, Rush University, Chicago, Illinois 60612,1 Johnson & Johnson Pharmaceutical Research and Development, LLC, Raritan, New Jersey 088692

Received 7 March 2005/ Returned for modification 10 April 2005/ Accepted 14 May 2005

Carbapenemases are rare in the United States. This is the first report of a United States nosocomial outbreak of pan-resistant Pseudomonas aeruginosa infections due to an integron-borne metallo-ß-lactamase, VIM-2. This emergence of carbapenemases on mobile genetic elements in the United States warrants surveillance.

* Corresponding author. Mailing address: 1900 W. Polk St., Rm. 1258, Chicago, IL 60612. Phone: (312) 864-4874. Fax: (312) 864-9497. E-mail: john_p_quinn{at}rush.edu.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3538-3540, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3538-3540.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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