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Antimicrobial Agents and Chemotherapy, August 2005, p. 3541-3543, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3541-3543.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

IS26-Associated In4-Type Integrons Forming Multiresistance Loci in Enterobacterial Plasmids

Vivi Miriagou,1* Alessandra Carattoli,2 Eva Tzelepi,1 Laura Villa,2 and Leonidas S. Tzouvelekis3

Laboratory of Bacteriology, Hellenic Pasteur Institute,1 Department of Microbiology, Medical School, University of Athens, Athens, Greece,3 Department of Infectious Diseases, Istituto Superiore di Sanita, Rome, Italy2

Received 25 January 2005/ Returned for modification 26 February 2005/ Accepted 29 April 2005

Three distinct multiresistant loci from enterobacterial plasmids each comprised an integron and an IS26-associated sequence. Sequence comparison suggested a common ancestral structure that derived from an IS26 insertion into the 5' conserved segment of an In4-type integron and evolved through acquisition of gene cassettes and IS26-mediated recruitment of additional resistance genes of diverse origin.

* Corresponding author. Mailing address: Laboratory of Bacteriology, Hellenic Pasteur Institute, Vas. Sofias 127, Athens 11521, Greece. Phone: 30-210-6478810. Fax: 30-210-6423498. E-mail: miriagou{at}mail.pasteur.gr.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3541-3543, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3541-3543.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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