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Antimicrobial Agents and Chemotherapy, August 2005, p. 3546-3549, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3546-3549.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Nystatin Induces Secretion of Interleukin (IL)-1ß, IL-8, and Tumor Necrosis Factor Alpha by a Toll-Like Receptor-Dependent Mechanism

Raymund R. Razonable,1,2* Martin Henault,2 Harold L. Watson,2 and Carlos V. Paya1,2

Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905,1 Lilly Research Laboratories, Indianapolis, Indiana 462852

Received 4 April 2005/ Returned for modification 30 April 2005/ Accepted 19 May 2005

Nystatin is an antifungal compound with potent proinflammatory properties. Herein, we demonstrate that nystatin induces interleukin (IL)-1ß, IL-8, and tumor necrosis factor alpha secretion through its activation of toll-like receptor 1 (TLR1) and TLR2. Hence, a TLR-dependent mechanism could serve as the molecular basis for the proinflammatory properties of nystatin.

* Corresponding author. Mailing address: Division of Infectious Diseases, Mayo Clinic College of Medicine, 200 First St. SW, Rochester, MN 55905. Phone: (507) 284-3747. Fax: (507) 284-3757. E-mail: Razonable.raymund{at}mayo.edu.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3546-3549, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3546-3549.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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