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Antimicrobial Agents and Chemotherapy, August 2005, p. 3558-3561, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3558-3561.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of Nelfinavir and Efavirenz in Antiretroviral-Naïve, Human Immunodeficiency Virus-Infected Subjects when Administered Alone or in Combination with Nucleoside Analog Reverse Transcriptase Inhibitors

Patrick F. Smith,1,6* Gregory K. Robbins,2,6 Robert W. Shafer,3,6 Hulin Wu,4,6 Song Yu,2,6 Martin S. Hirsch,2,6 Thomas C. Merigan,3,6 Jeong-Gun Park,2,6 Alan Forrest,1,6 Margaret A. Fischl,5,6 Gene D. Morse,1,6 and the ACTG 384-5006 Team6

University at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Buffalo, New York,1 Harvard University, School of Medicine, Boston, Massachusetts,2 Stanford University, School of Medicine, Palo Alto, California,3 University of Rochester School of Medicine and Dentistry, Rochester, New York,4 University of Miami, School of Medicine, Miami, Florida,5 Adult AIDS Clinical Trials Group, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland6

Received 2 December 2004/ Returned for modification 16 January 2005/ Accepted 5 May 2005

Pharmacokinetic studies were conducted with human immunodeficiency virus-infected patients receiving efavirenz, nelfinavir, or both agents at weeks 4 and 32. Reductions of 25% and 45% were observed in the mean nelfinavir area under the concentration-time curve and minimum concentration of the drug in serum, and there was a 31% more rapid half-life for patients receiving both drugs compared to patients receiving nelfinavir alone. There were no significant differences in efavirenz pharmacokinetics.

* Corresponding author. Mailing address: Adult ACTG Pharmacology Support Laboratory, Laboratory for Antiviral Research, Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, 219 Cooke Hall, University at Buffalo, Buffalo, NY 12460. Phone: (716) 645-2828, ext. 242. Fax: (716) 645-2886. E-mail: pfsmith{at}buffalo.edu.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3558-3561, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3558-3561.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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