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Antimicrobial Agents and Chemotherapy, August 2005, p. 3562-3565, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3562-3565.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vivo Transfer of Plasmid-Encoded ACC-1 AmpC from Klebsiella pneumoniae to Escherichia coli in an Infant and Selection of Impermeability to Imipenem in K. pneumoniae

Laboratoire d'Études de Génétique Bactérienne dans les Infections de l'Enfant (EA 3105), Université Denis Diderot-Paris VII, Service de Microbiologie,¹ Service de Chirurgie viscérale, Hôpital Robert Debré,³ Laboratoire de Bactériologie, UPRES EA 2392, UFR Saint-Antoine, Université Paris VI, Paris, France²

Received 22 February 2005/ Returned for modification 24 March 2005/ Accepted 30 May 2005

We describe in vivo selection of a Klebsiella pneumoniae strain with diminished imipenem susceptibility attributable to plasmid-encoded ACC-1 ß-lactamase production and loss of a 36-kDa major outer membrane protein, together with transfer of this plasmid from K. pneumoniae to Escherichia coli in a Tunisian infant.

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