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Antimicrobial Agents and Chemotherapy, August 2005, p. 3593-3597, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3593-3597.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Integron-Encoded GES-Type Extended-Spectrum ß-Lactamase with Increased Activity toward Aztreonam in Pseudomonas aeruginosa

Laurent Poirel,1 Laura Brinas,1,2 Nicolas Fortineau,1 and Patrice Nordmann1*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 K.-Bicêtre, France,1 Area de Bioquimica y Biologia Molecular, Universidad de La Rioja, 26006 Logrono, Spain2

Received 15 February 2005/ Returned for modification 22 March 2005/ Accepted 4 May 2005

A Pseudomonas aeruginosa strain expresses an extended-spectrum ß-lactamase, GES-9, which differs from GES-1 by a Gly243Ser substitution, is inhibited by clavulanic acid and imipenem, and hydrolyzes aztreonam. The blaGES-9 gene was located inside a class 1 integron structure containing two copies of a novel insertion sequence belonging to the IS1111 family.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3593-3597, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3593-3597.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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