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Antimicrobial Agents and Chemotherapy, September 2005, p. 3919-3921, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3919-3921.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Mutations Associated with Sulfadoxine-Pyrimethamine and Chlorproguanil Resistance in Plasmodium falciparum Isolates from Blantyre, Malawi

Alisa P. Alker,1* Victor Mwapasa,2 Anne Purfield,3 Stephen J. Rogerson,4 Malcolm E. Molyneux,5 Deborah D. Kamwendo,6 Eyob Tadesse,7 Ebbie Chaluluka,5 and Steven R. Meshnick1,2,3

Department of Epidemiology, UNC Chapel Hill School of Public Health, Chapel Hill, North Carolina,1 Department of Community Health, College of Medicine, Blantyre, Malawi,2 Deparment of Microbiology, UNC Chapel Hill School of Medicine, Chapel Hill, North Carolina,3 Department of Medicine, University of Melbourne, Parkville, Victoria 3052, Australia,4 Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre, Malawi,5 Department of Epidemiology, University of Michigan, Ann Arbor, Michigan,6 Department of Obstetrics and Gynecology, College of Medicine, Blantyre, Malawi7

Received 21 April 2005/ Returned for modification 24 May 2005/ Accepted 22 June 2005

We conducted a prevalence study of mutations in Plasmodium falciparum that are associated with antifolate resistance in Blantyre, Malawi. The dihydrofolate reductase 164-Leu mutation, which confers resistance to both pyrimethamine and chlorproguanil, was found in 4.7% of the samples. Previously unreported mutations in dihydropteroate synthase were also found.

* Corresponding author. Mailing address: Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC 27599-7435. Phone: (919) 843-4384. Fax: (919) 966-0584. E-mail: alker{at}unc.edu.

Antimicrobial Agents and Chemotherapy, September 2005, p. 3919-3921, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3919-3921.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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