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Antimicrobial Agents and Chemotherapy, September 2005, p. 3933-3936, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3933-3936.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Activity and Killing Effect of Uperin 3.6 against Gram-Positive Cocci Isolated from Immunocompromised Patients

Andrea Giacometti,1* Oscar Cirioni,1 Wojciech Kamysz,2 Carmela Silvestri,1 Alberto Licci,1 Giuseppina D'Amato,1 Piotr Nadolski,2 Alessandra Riva,1 Jerzy Lukasiak,2 and Giorgio Scalise1

Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, Ancona, Italy,1 Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland2

Received 5 March 2005/ Returned for modification 16 May 2005/ Accepted 30 June 2005

The in vitro activity of uperin 3.6, alone or combined with six antibiotics, against gram-positive cocci, including Rhodococcus equi, methicillin-resistant staphylococci, and vancomycin-resistant enterococci, was investigated. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when uperin 3.6 was combined with clarithromycin and doxycycline.

* Corresponding author. Mailing address: Institute of Infectious Diseases and Public Health, c/o Ospedale Regionale, via Conca, 71, Ancona, I-60020, Italy. Phone: 39-071-5963715. Fax: 39-071-5963468. E-mail: anconacmi{at}interfree.it.

Antimicrobial Agents and Chemotherapy, September 2005, p. 3933-3936, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3933-3936.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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