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Antimicrobial Agents and Chemotherapy, September 2005, p. 3955-3958, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3955-3958.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Correlation between Ceftriaxone Resistance of Salmonella enterica Serovar Typhimurium and Expression of Outer Membrane Proteins OmpW and Ail/OmpX-Like Protein, Which Are Regulated by BaeR of a Two-Component System

Wensi S. Hu,* Pei-Chuan Li,{dagger} and Chao-Yin Cheng{ddagger}

Institute of Biotechnology in Medicine, School of Medical Technology and Engineering, National Yang-Ming University, Taipei, Taiwan

Received 31 December 2004/ Returned for modification 21 February 2005/ Accepted 1 July 2005

Mutant 7F2 of Salmonella enterica serovar Typhimurium has a transposon inserted in the regulator gene baeR of a two-component system and showed a more-than-fourfold reduction in resistance to ceftriaxone. Complementation analysis suggested an association among the outer membrane proteins OmpW and STM3031, ceftriaxone resistance, and baeR.

* Corresponding author. Mailing address: Institute of Biotechnology in Medicine, School of Medical Technology and Engineering, National Yang-Ming University, 155, Li-Nong St., Sec. 2, Peitou, Taipei, Taiwan 112. Phone: 886-2-2826-7151. Fax: 886-2-2826-4092. E-mail: huws{at}ym.edu.tw.

{dagger} Present address: The Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, Taiwan 115.

{ddagger} Present address: Institute of Molecular Biology, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, Taiwan 115.

Antimicrobial Agents and Chemotherapy, September 2005, p. 3955-3958, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3955-3958.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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