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Antimicrobial Agents and Chemotherapy, September 2005, p. 3959-3962, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3959-3962.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Effect of Simvastatin, an Established Lipid-Lowering Drug, on Pulmonary Chlamydia pneumoniae Infection in Mice

Leena Erkkilä,1* Matti Jauhiainen,2 Kirsi Laitinen,3 Kristiina Haasio,4 Terttu Tiirola,2 Pekka Saikku,1,5 and Maija Leinonen1

National Public Health Institute, Department of Viral Diseases and Immunology, Oulu, Finland,1 National Public Health Institute, Department of Molecular Medicine, Helsinki, Finland,2 Department of Public Health, University of Helsinki, Helsinki, Finland,3 Orion Pharma, Espoo, Finland,4 Department of Medical Microbiology, University of Oulu, Oulu, Finland5

Received 11 October 2004/ Returned for modification 8 February 2004/ Accepted 1 July 2005

The effects of simvastatin treatment on Chlamydia pneumoniae lung infection, inflammation, and serum lipids in mouse model were studied. Simvastatin decreased viable chlamydial counts and increased inflammatory cell infiltrates in the lung tissue, suggesting that simvastatin treatment had both antichlamydial and immunomodulatory effects during an acute C. pneumoniae infection.

* Corresponding author. Mailing address: National Public Health Institute, Department of Viral Diseases and Immunology, P.O. Box 310, 90101 Oulu, Finland. Phone: 358 8 5376219. Fax: 358 8 5376251. E-mail: leena.erkkila{at}ktl.fi

Antimicrobial Agents and Chemotherapy, September 2005, p. 3959-3962, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3959-3962.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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