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Antimicrob Agents Chemother. 1974 March; 5(3): 318-322
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Herpes Simplex Virus Skin Infection in Hairless Mice: Treatment with Antiviral Compounds

Richard J. Klein, Alvin E. Friedman-Kien and Eileen Brady

1 Departments of Microbiology and Dermatology, New York University School of Medicine, New York, New York 10016

ABSTRACT

A hairless mouse-herpes simplex virus skin infection experimental model was used to evaluate the efficacy of the antiviral compounds 9-ß-D-arabinofuranosyladenine (ara-A), 5-iodo-2'-deoxyuridine (IUdR), and 6-azauridine (aza-U). Ara-A and IUdR, when administered intraperitoneally by several different dosage schedules, reduced the severity of cutaneous herpetic lesions and the incidence of paralysis and increased significantly the number of survivors. A more rapid healing of the lesions and an increase in the mean survival time also was observed. A delay of 24 to 48 h in the initiation of treatment after the infection was more effective than treatments started at the time of inoculation. Treatment with ara-A was somewhat superior to that with IUdR, but aza-U was totally ineffective. Enhancement of the evolution of the infection was noted after treatment with aza-U.

Antimicrob Agents Chemother. 1974 March; 5(3): 318-322
Copyright © 1974 American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Park, N.-H., Pavan-Langston, D., McLean, S. L., Lass, J. H. (1980). Acyclovir Topical Therapy of Cutaneous Herpes Simplex Virus Infection in Guinea Pigs. Arch Dermatol 116: 672-675 [Abstract]  


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