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Antimicrobial Agents and Chemotherapy, January 2006, p. 226-229, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.226-229.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

First Detection of Metallo-ß-Lactamase VIM-2 in Pseudomonas aeruginosa Isolates from Colombia

Maria Virginia Villegas,1 Karen Lolans,2 Maria del Rosario Olivera,1 Carlos José Suarez,1 Adriana Correa,1 Anne Marie Queenan,3 John P. Quinn,2* the Colombian Nosocomial Resistance Study Group

CIDEIM (International Center for Medical Research and Training), Cali, Colombia,1 John Stroger Hospital and Chicago Infectious Disease Research Institute, Chicago, Illinois,2 Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, New Jersey3

Received 20 July 2005/ Returned for modification 4 September 2005/ Accepted 19 October 2005

Carbapenem resistance rates in Pseudomonas aeruginosa isolates in Colombia, as in many South American countries, are high for reasons that remain unclear. From our nationwide network, we describe the first detection of the metallo-ß-lactamase VIM-2 in clinical isolates of P. aeruginosa from multiple cities within Colombia. Metallo-ß-lactamases were not detected in the two centers with the highest imipenem resistance rates. Clonality was noted in five of the eight centers with strains meeting the criteria for molecular typing. The high carbapenem resistance in P. aeruginosa in Colombia may be attributable to a combination of factors, including the presence of metallo-ß-lactamases and nosocomial transmission.

* Corresponding author. Mailing address: 1900 W. Polk, Rm. 1258, Chicago, IL 60612. Phone: (312) 864-4874. Fax: (312) 864-9522. E-mail: ESBLman{at}yahoo.com.

Antimicrobial Agents and Chemotherapy, January 2006, p. 226-229, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.226-229.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Strateva, T., Yordanov, D. (2009). Pseudomonas aeruginosa - a phenomenon of bacterial resistance. J Med Microbiol 58: 1133-1148 [Abstract] [Full Text]  
  • Queenan, A. M., Bush, K. (2007). Carbapenemases: the Versatile {beta}-Lactamases. Clin. Microbiol. Rev. 20: 440-458 [Abstract] [Full Text]  
  • Villegas, M. V., Kattan, J. N., Correa, A., Lolans, K., Guzman, A. M., Woodford, N., Livermore, D., Quinn, J. P., and the Colombian Nosocomial Bacterial Resistance, (2007). Dissemination of Acinetobacter baumannii Clones with OXA-23 Carbapenemase in Colombian Hospitals. Antimicrob. Agents Chemother. 51: 2001-2004 [Abstract] [Full Text]  


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