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Antimicrobial Agents and Chemotherapy, January 2006, p. 226-229, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.226-229.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

First Detection of Metallo-ß-Lactamase VIM-2 in Pseudomonas aeruginosa Isolates from Colombia

CIDEIM (International Center for Medical Research and Training), Cali, Colombia,¹ John Stroger Hospital and Chicago Infectious Disease Research Institute, Chicago, Illinois,² Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, New Jersey³

Received 20 July 2005/ Returned for modification 4 September 2005/ Accepted 19 October 2005

Carbapenem resistance rates in Pseudomonas aeruginosa isolates in Colombia, as in many South American countries, are high for reasons that remain unclear. From our nationwide network, we describe the first detection of the metallo-ß-lactamase VIM-2 in clinical isolates of P. aeruginosa from multiple cities within Colombia. Metallo-ß-lactamases were not detected in the two centers with the highest imipenem resistance rates. Clonality was noted in five of the eight centers with strains meeting the criteria for molecular typing. The high carbapenem resistance in P. aeruginosa in Colombia may be attributable to a combination of factors, including the presence of metallo-ß-lactamases and nosocomial transmission.

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