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Antimicrobial Agents and Chemotherapy, January 2006, p. 294-297, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.294-297.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Pentamidine Is Active in a Neutropenic Murine Model of Acute Invasive Pulmonary Fusariosis

Michail S. Lionakis,^1,2, Georgios Chamilos,^1, Russell E. Lewis,^1,3 Nathan P. Wiederhold,³ Issam I. Raad,¹ George Samonis,² and Dimitrios P. Kontoyiannis^1,3*

Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas,¹ Medical School of the University of Crete, Heraklion, Greece,² College of Pharmacy, University of Houston, Houston, Texas³

Received 11 August 2005/ Returned for modification 12 September 2005/ Accepted 12 October 2005

We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice.

These authors contributed equally to this work.