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Antimicrobial Agents and Chemotherapy, January 2006, p. 336-343, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.336-343.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

VraSR Two-Component Regulatory System and Its Role in Induction of pbp2 and vraSR Expression by Cell Wall Antimicrobials in Staphylococcus aureus{dagger}

Shaohui Yin,1 Robert S. Daum,1,2,3 and Susan Boyle-Vavra1*

Department of Pediatrics,1 Committee on Microbiology,2 Committee on Molecular Medicine, The University of Chicago, Chicago, Illinois 606373

Received 15 June 2005/ Returned for modification 8 August 2005/ Accepted 18 October 2005

The VraS/VraR two-component system (VraSR) regulates transcriptional induction of penicillin-binding protein 2 (encoded by pbp2) by vancomycin in Staphylococcus aureus. We have now defined the vraSR operon and determined that its induction by ß-lactams as well as by vancomycin is autoregulated. Induction of the pbp2 and vraSR operons by ß-lactams and related compounds within 1 hour after exposure to the antimicrobials was dependent on vraS. However, when a disk diffusion assay that can detect induction of genes over an extended time period was used, induction of the pbp2 operon was mediated by some ß-lactams, including oxacillin; this induction was independent of vraS.

* Corresponding author. Mailing address: Department of Pediatrics, The University of Chicago, 5841 S. Maryland Ave., MC 6054, Chicago, IL 60637. Phone: (773) 702-6401. Fax: (773) 702-1196. E-mail: sboyleva{at}midway.uchicago.edu.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, January 2006, p. 336-343, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.336-343.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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