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Antimicrobial Agents and Chemotherapy, January 2006, p. 344-347, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.344-347.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

5-Nitroimidazole Drugs Effective against Metronidazole-Resistant Trichomonas vaginalis and Giardia duodenalis

Queensland Institute of Medical Research and ACITHN, 300 Herston Rd., Brisbane, Queensland 4006, Australia,¹ School of Population Health, University of Queensland, Brisbane, Queensland 4072, Australia,² Laboratoire de Chimie Organique Pharmaceutique, LCOP-UMR CNRS 6517, Université de la Méditerranée, Faculté de Pharmacie, 27 Bd. J Moulin, 13385 Marseille Cedex 05, France³

Received 1 June 2005/ Returned for modification 22 June 2005/ Accepted 12 October 2005

Metronidazole (Mz)-resistant Giardia and Trichomonas were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-resistance among established 5-nitromidazole antiparasitic drugs.

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